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Therapeutic Innovation
COORDINATOR: DR. FRANCESC ARTIGAS PÉREZ (G02 – Agencia Estatal Consejo Superior de Investiga- ciones Científicas)
Some of the most relevant results of the groups form- ing the programme deserving mention are the appli- cation for / registration of six patents (three of these with the CIBER among the applying institutions) and the publication of over forty articles in 1st decile journals. Some significant texts are publications in journals such as Lancet, Nature, Cancer Cell, Nature Genetics and Molecular Psychiatry. Different articles have also been published in other leading journals in the field, such as American Journal of Psychiatry, Pharmacology & Therapeutics, Cerebral Cortex, Neu- roscience and Biobehavioral Reviews y Schizophre- nia Bulletin. A large percentage of these publications are multi-centre, due to the existence of intra-CIBER cooperation (between CIBERSAM and other CIBER areas) as well as national and international cooper- ation.
Apart from all this the groups in the programme have been particularly active in fundraising, hav- ing obtained 14 competitive projects from pub- lic bodies (MINECO- PI14/00815, PI14/00860, PI13/01102, PI14/00723, PI14/00286, PIE15/00079, PIE14/00031, PI14/00639, PI14/00918 and DTS14/001) and from different national- (Alicia Ko- plowitz, FIPSE, Mapfre) and international foundations (The Stanley Medical Research Institute).
Some of the prizes and awards obtained by members of the group are:
• ECNP Neuropsychopharmacology Award, Euro- pean College of Neuropsychopharmacology, Dr. Francesc Artigas (first Spanish scientist to receive this award).
• Appointment as “Honoris Causa” doctor by the Universitat de València (UV), Dr. Eduard Vieta.
• Admittance as Full Academy Member of the Real Academia de Medicina de Cantabria, Dr. Benedic- to Crespo Facorro.
• Reference Researcher Award, Sociedad Española de Psiquiatría Biológica (SEPB), Dr. Antoni Bena- barre.
• Emerging Researcher Award, Sociedad Española de Psiquiatría Biológica (SEPB), Dr. Íria Grande.
• 2nd Mental Health Award of the Centro Hospita- lario Padre Menni in Cantabria for the programme
• andresearchteamofFirstEpisodesofPsychosis in Cantabria (PAFIP) directed by Dr. Benedicto Cre- spo Facorro.
• Award of the Asociación Cántabra para la Pa- tología Dual y otras Alteraciones Mentales (PADU- CAN) for the professional career of Dr. Benedicto Crespo Facorro and the PAFIP health- care-research team that he directs.
Some of the scientific achievements made by differ- ent groups in the programme are:
• Implication of AMPA receptors in the molecular mechanisms involved in the antidepressant ther- apeutic response to Deep Brain Stimulation (DBS).
• Identification of risk/protection factors involved in first psychotic episodes related with BDNF and TrkB receptors.
• Identification of the neurobiological causes un- derlying the appearance of anxiety as a result of suffering chronic pain.
• Establishment of fast-acting antidepressant ef- fects by the use of siRNA targeting the 5-HT trans- porter.
• Development of a new model of screening of an- tipsychotics based on slow cortical oscillations.
• Identification of induced neurobiological effects in a model of schizophrenia by chronic phencycli- dine.
• Preparation of clinical recommendations for work with relatives of patients with bipolar disorder.
• Functional rehabilitation improves the autonomy and general function of patients with bipolar dis- order.
• Proving the predictive value of the cognitive re- serve in bipolar disorder.
• Preparation of a document on bipolar disorder which highlights the importance of tackling the disease translationally.
Scientific Programmes
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