Page 29 - CIBEREHD-2015-eng

The samples deposited at the Biobank have been re- quested, during its six years’ operation, by sound and competitive research groups. In 2015, more specifi- cally, 1253 samples were assigned, 41 of which were steatotic livers (41 patients).
The Biobanco La Fe forms part of the “Biobanks Plat- form (PT13/0010/0026. AES-2013)” cooperating in four currently active programmes/work lines: “Pro-
Bioinformatics
The Bioinformatics platform has taken an active part in the operation of this CIBER, as is vouched for by the 13 publications reflecting their support in 2015. Special attention should go to the contribution made in the areas of colon cancer, specifically the group directed by Dr Toni Castells (G0016) whose bioinformatic work was directed and performed by our group. Two important publications are:
• Whole-exome sequencing identifies rare path- ogenic variants in new predisposition genes for familial colorectal cancer. Esteban-Jurado C, Vi- la-Casadesús M, Garre P, Lozano JJ, Pristoupi- lova A, Beltran S, Muñoz J,Ocaña T, Balaguer F, López-Cerón M, Cuatrecasas M, Franch-Expósito S, Piqué JM, Castells A, Carracedo A, Ruiz-Ponte C, Abulí A, Bessa X, Andreu M, Bujanda L, Caldés T, Castellví-Bel S.Genet Med. 2015 Feb;17(2):131- 42. doi: 10.1038/gim.2014.89. Epub 2014 Jul 24.(IF: 7.329).
• Patterns of somatic uniparental disomy identi- fy novel tumor suppressor genes in colorectal cancer. Torabi K, Miró R, Fernández-Jiménez N, Quintanilla I, Ramos L, Prat E, del Rey J, Pujol N, Killian JK, Meltzer PS, Fernández PL, Ried T, Lo- zano JJ, Camps J, Ponsa I.Carcinogenesis. 2015 Oct;36(10):1103-10. doi: 10.1093/carcin/bgv115. Epub 2015 Aug 4.(IF:5,33).
In the liver transplantation area our group has per- formed and directed bioinformatic work to propose a signature predicting rejection in HCV-negative patients, cooperating with other groups from the CIBER and Dr Sánchez-Fueyo (King’s College of London).
gramme for collections with strategic value”, “Net- work Services Management”, “R+D+i Programmes (Management Technologies and Quality Control Pro- grammes)” and “Training”. La Fe Biobank has taken part in the (“ISBER Proficiency Test”) international quality control programme in 2012 and 2015 and has been certified according to UNE-EN ISO 9001:2008 Standard on Quality Management.
• Molecular Characterization of Acute Cellular Re- jection Occurring During Intentional Immuno- suppression Withdrawal in Liver Transplantation. Bonaccorsi-Riani E, Pennycuick A, Londoño MC, Lozano JJ, Benítez C, Sawitzki B, Martínez-Picola M, Bohne F, Martínez-Llordella M, Miquel R, Ri- mola A, Sánchez-Fueyo.Am J Transplant. 2016 Feb;16(2):484-96.(IF:5.683).
Our group has led the bioinformatic work of differ- ent projects cooperating with CIBER groups: Dr Pere Ginés (G0020) and Vrije Universiteit Brussel, to inte- grate gene expression data on mRNA and microR- NA and learning of mechanisms of activation of he- patic stellate cells.
• Integrative miRNA and Gene Expression Profiling Analysis of Human Quiescent Hepatic Stellate Cells.Coll M, El Taghdouini A, Perea L, Mannaerts I, Vila-Casadesús M, Blaya D, Rodrigo-Torres D, Affò S, Morales-Ibanez O, Graupera I, Lozano JJ, Najimi M, Sokal E, Lambrecht J, Ginès P, van Grunsven LA, Sancho-Bru P.Sci Rep. 2015 Jun 22;5:11549. doi: 10.1038/srep11549.(IF:5,578).
Our group took part in the achievement of financed projects and/or projects with R+d+i companies such as for example:
• Title: Kit easy-CCR: Development of a diagnosis kit for early detection of colorectal cancer by a non-invasive method in plasma based on the ex- pression of miRNAs. Organisation: Ministry of the Economy and Competitiveness. Call: Challeng- es-Cooperation 2015 (Case file: RTC- 2015-3850- 1). Duration: 2015-2018.
• Coordinated project. Coordinating entity: Ama- dix. PI for CIBER: Meritxell Gironella.
Amount: 1,549,174€ (CIBER part: 171,800€).
Platforms
CIBEREHD I Annual report 2015 I 29