Page 48 - MemoriaDEM-Eng

RESEARCH GROUPS

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P3
Laboratory of Molecular Endocrinology
PROGRAMME:

Group Members
Lead Researcher

STAFF MEMBERS
Burks, Deborah

Acosta Umanzor, Carlos Rene
óNoon, Luke

Contact:
Centro de Investigacin Príncipe Felipe ASSOCIATED MEMBERS
Leal, Aranxa
Avenida del Autopista del Saler, 16. 46012 Valencia
Phone: (+34) 96 328 96 80 Moreno Gimeno, Inmaculada
Sanz Gonzlez, Silvia Mara
E.mail: [email protected] · Website: www.cipf.es

Main lines of research

The incidence of diabetes and obesity is increasing at alarming rates throug-
hout the world, creating a significant social and economic burden in industria-

lised countries. Defective expression or function of insulin signalling pathway

components, such as the IRS (insulin receptor substrate) proteins, causes
insulin resistance, which occurs with normal ageing but is also a hallmark

of disease states such as diabetes. The overall aim of our research is to un-

derstand precisely how impaired insulin signalling contributes to metabolic 13
diseases. Our research therefore focuses on several major themes:
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• Regulation of the cell cycle in pancreatic beta cells. R
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• The role of IRS-2 signals in the differentiation of human pluripotent stem
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L R
cells to progenitors of pancreas and liver. A
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• IRS-2 signalling in the regulation of neuronal function. N
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• The role of insulin/IGF-I signalling in diabetic retinopathy. /
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• The role of IRS2 in adipocyte progenitors and development of obesity.
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ER
B
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