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Most relevant CuRRayhuRChaRdeRICholsonellseboulunGIMMInGton
d, bosCh F, jIMénez V, yeo Gs, o’RahIlly s, ashCRoFt FM, Coll aP, CoX Rd. Adult onset
scientific global loss of the fto gene alters body composition and metabolism in the mousep.

articles
los Genetics. 2013 ;9(1):e1003166.

• anGuela XM, taFuRo s, RoCa C, Callejas d, aGudo j, obaCh M, RIbeRa a, Ruzo a, Mann Cj,

Casellas a, bosCh F. Non-viral-mediated hepatic expression of igf-i increases treg le-
vels and suppresses autoimmune diabetes in mice. Diabetes. 2013 ;62(2):551-560.

• C d, M C, a e, l R, G I, R C, a a, R- G R, M-
allejasannyusoaGeRIFolloCandaluzuIzdeoPeGuIon
tané j, Muñoz s, FeRRé t, hauRIGot V, zhou s, RubeRte j, MInGozzI F, hIGh k, GaRCía F and
b F. Treatment of diabetes and long-term survival after insulin and glucokinase
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gene therapy. Diabetes. 2013;62 (5):1718-1729.

• VIllaCaMPa P, RIbeRa a, Motas s, RaMíRez l, GaRCía M, de la VIlla P, hauRIGot V & bosCh F.
Insulin-like growth factor i (igf-i)-induced chronic gliosis and retinal stress lead to é

neurodegeneration in a mouse model of retinopathy. Journal of Biological Chemistry. é

2013;228(24):17631-42.

• jIMnez V, Muñoz s, Casaña e, Mallol C, elIas I, jaMbRIna C, RIbeRa a, FeRRe t, FRanCkhauseR
F & bosCh F. In vivo aav-mediated genetic engineering of white and brown adipose ó

tissue in adult mice. Diabetes. 2013;62(12):4012-22.
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Highlights
Our group is participating in the EU, Programme “Capacities”-Call “FP7-INFRAS-
TRUCTURES-2012-1 “The European infrastructure for phenotyping and archiving

of model mammalian genomes (Infrafrontier-I3)”, for high-throughput mouse

phenotyping. We are also involved in the “International Mouse Phenotyping Con- é
sortium”, initiative including Mouse Clinics around the world (Europe, United Sta-

tes, Canada, Australia and China).

We are part of the collaborative project BETASEL-“In vivo selection of genes and
miRNAs improving betacell mass”, funded by the Juvenile Diabetes Research

Foundation, together with Dr. Mauro Giacca (Trieste, Italy), and Dr. Philippe Hal-

ban (Geneva, Switzerland).

On the other hand, our group is granted by European Foundation for the Study
of Diabetes (EFSD)/MSD Programme 2013 for the project “Unravelling of novel

factors capable of inducing Browning of WAT in vivo”, aiming to identify new me-

chanisms involved in white adipose tissue browning, which may open the way for
new treatment of diabetes and obesity. We also count with funds from Ministerio

de Educacin y Ciencia, Plan Nacional I+D+I (SAF2011-24698) “Ingeniería ge-
ntica del msculo esqueltico para expresar insulina y/o glucoquinasa para el

tratamiento de la diabetes mellitus”, a project aiming to develop new gene thera-

py approaches for the treatment of diabetes based on genetic engineering of the
skeletal muscle to increase glucose uptake and produce insulin.
13
Our group, from the Autonomous University of Barcelona, together with Ciberdem 20
T
and the German Center for Diabetes Research (DZD), organized the “XII INTER- OR
P
NATIONAL SYMPOSIUM ON INSULIN RECEPTORS AND INSULIN ACTION: NEW RE
OPPORTUNITIES FOR THE PREVENTION AND TREATMENT OF DIABETES IN THE L
A
XXI CENTURY (IR2013)”. This symposium, held in Barcelona form 7th to 9th of NU
November 2013 follows a long tradition since 1981 and counts with the participa- N
A
tion of the best international experts in the field. IR2013 has been a great success M /
E
for the 300 participants.
D
ER
B
CI

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