Page 18 - CIBERSAM-2015-eng

Scientific Programmes
Depression
COORDINATOR: DR. VÍCTOR PÉREZ SOLA (G21 – Hospital de la Santa Creu i Sant Pau)
The basic and clinical lines of research carried out by the groups forming the Depression Programme led to obtaining relevant results in 2015 which mate- rialised in the following achievements:
• Anti-depressant effectiveness of intranasal deliv- ery of interference RNA (siRNA) for silencing the serotonin transporter.
• Study of peripheral markers of oxidative stress and inflammation in Major Depression Disorder.
• Impact of psychosocial difficulties in patients with depression: PARADISE study.
• Anti-depressant effectiveness of DBS: first ran- domised clinical assay of Deep Brain Stimulation
• Potential of cannabidiol as a fast-acting antide- pressant therapy: neurochemical, molecular and cellular study in animals.
• Evaluation of olfactory bulbectomy as an animal model of depression.
• Characterisation of the antidepressant action mechanism of Deep Brain Stimulation: the impli- cation of the AMPA receptor.
in severe treatment-resistant depression.
• Development of a new technique for temporal determination of cortisol in hair as a biological marker of stress and depression.
18 I Annual report 2015 I CIBERSAM