Page 99 - CIBERES-2015-eng

Most relevant scientific articles
Research Groups
Diez-Martínez r., De Paz h.D., garCía-FernánDez e., BustaMante n., euLer C.W., FisChetti v.a. et aL. A novel chimeric phage lysin with high in vitro and in vivo bacteri- cidal activity against Streptococcus pneumoniae. Journal of Antimicrobial Chemotherapy. 2015;70(6):1763-1773.
riCo-Lastres P., Diez-Martínez r., igLesias-Bexiga M., BustaMante n., aLDriDge C., heseK D. et aL. Substrate recognition and catalysis by LytB, a pneumococcal pep- tidoglycan hydrolase involved in virulence. Scientific Re- ports. 2015;5.
CaMPanero-rhoDes M.a., LLoBet e., BengoeChea J.a., so- Lis D.. Bacteria microarrays as sensitive tools for exploring
Highlights
RESULTS
• The glycosylation patterns and recognition by several lectins of the innate immune system of nontypeable Haemophilus influenzae (NTHi) strain 375, a panel of isogenic mutants express- ing sequentially truncated lipooligosaccharide and other clinical isolates of this bacterium have been characterized, in collaboration with Dr. J. Garmendia (Group 8 of CIBERES). A simi- lar study using S. pneumoniae, as Gram+ model bacterium, and related species, has been initiat- ed, in collaboration with group 2 of CIBERES (Dr. E. García). In addition, bacteria microarrays have been proved to be useful for the detection of re- ceptors on the pneumococcal surface.
• Newdesignermicroarrayshavebeendeveloped for the study of receptors on the surface of live bacteria, using as model bacterium the E. coli strain UTI89, which expresses the best charac- terized bacterial adhesin, FimH.
• New bacteriolytic enzymes active against S. pneumoniae, S. pyogenes and other Gram-positive pathogens have been developed and character- ized, in a colaboration with Group 2 of CIBERES.
pathogen surface epitopes and recognition by host recep- tors. RSC Advances. 2015;5(10):7173-7181.
singh a.K., BerBis M.a., BaLLMann M.z., KiLCoyne M., Me- nenDez M., nguyen t.h. et aL. Structure and sialyllactose binding of the carboxy-terminal head domain of the fibre from a siadenovirus, Turkey adenovirus 3. PLoS ONE. 2015;10(9).
soLis D., Bovin n.v., Davis a.P., JiMenez-BarBero J., roMero a., roy r. et aL. A guide into glycosciences: How chemistry, biochemistry and biology cooperate to crack the sugar code. Biochimica et Biophysica Acta - General Subjects. 2015;1850(1):186-235.
• Identification of a new family of compounds that inhibit the activity of the major pneumococcal autolytic enzyme, LytA, and have also antimi- crobial activity, by means of high-through put screening of chemical libraries of compounds.
INTERNATIONAL AND NATIONAL ACTIVE PROJECTS:
• 2011-2015. Dynamic interactive nanosystems (EU; FP7-ITN-GA:289003).
• 2012-2016. The Sugar Code: from (bio)chemi- cal concept to clinics (UE; FP7-PEOPLE-2012- ITN-317297).
• 2012-2016. Bioinformatics Integrative platform for structure-based drug discovery BIPPED2 (CAM; S2010/BMD-2457).
• 2013-2015. Exploring exogenous and endoge- nous factors as tools for the control of infectious and immune processes (MINECO; BFU2012- 36825).
Institución: Agencia Estatal Consejo Superior de Investigaciones Científicas
Contact: Instituto de Química Fisíca Rocasolano · C/ Serrano, 119. 28006 Madrid · Tel.: 91 561 94 00 E.mail: [email protected]
CIBERES I Annual report 2015 I 99