Page 79 - CIBERES-2015-eng

Most relevant scientific articles
Research Groups
Lorente J.a., BaLLen-Barragan a., herrero r., esteBan a.. Acute respiratory distress syndrome: Does histology matter?. Critical Care. 2015;19(1):-.
Martínez-Caro L., nin n., sánChez-roDríguez C., Ferrue- Lo a., eL assar M., De PauLa M. et aL. Inhibition of nitro-ox- idative stress attenuates pulmonary and systemic injury induced by high-tidal volume mechanical ventilation. Shock. 2015;44(1):36-43.
CouDroy r., JaMet a., PenueLas o., thiLLe a.W.. Use of Type III procollagen measurement as predictor of lung fibroproliferation in ARDS: early measurement for earlier antifibroproliferative therapy?. Intensive Care Medicine. 2015;41(6):1159-1160.
Highlights
In the line of ARDS, we have worked at four levels. At the cellular level with the model of stretch of al- veolar cells, analyzing the response of inflammatory mediators, microRNAs and cell-binding proteins. At the level of our ex-vivo rat model, we analyzed asso- ciation of the microRNA to 27, as well as after his inhibiting. At the vivo level, with the model of VILI, we analyzed the inhibition of nitro-oxidative stress on pulmonary and vascular injury. At the human level, we have analyzed, along with the Group at the Uni- versity of Poitiers Type III procolagen as a predictor of fribroproliferacion in the lung in the ARDS.
One of the most important findings of our group, has been the description of a fenotype that is char- acteristic of patients with clinical criteria for ARDS and histological pattern of Diffuse Alveolar Dam- age. The mechanical ventilation line has led to re- sults more relevant analysis of the effect of sedation
sutherasan y., PenueLas o., MurieL a., vargas M., Fru- tos-vivar F., Brunetti i. et aL. Management and out- come of mechanically ventilated patients after cardiac arrest. Critical Care. 2015;19(1):-.
MurieL a., PenueLas o., Frutos-vivar F., arroLiga a.C., aBraira v., thiLLe a.W. et aL. Impact of sedation and an- algesia during noninvasive positive pressure ventilation on outcome: a marginal structural model causal analysis. Intensive Care Medicine. 2015;41(9):1586-1600.
in the evolution of the ventilation not invasive, the evolution of patients with mechanical ventilation af- ter a cardiac arrest , and the incidence and outcome of the acquired muscle weakness in ICU, in patients with mechanical ventilation. This line, in a wide in- ternational cooperation, remains very active. At this moment we have two manuscripts under review (ability to predict prolonged mechanical ventilation, and the effect of hypercapnia on the outcome of pa- tients with VM).
In the line of prevention of respiratory infections, we have studied in a model of rat in vivo with selective digestive decontamination, the effect of this in ani- mals with and without harmful mechanical ventila- tion. This study has been the thesis of a member of the Group (Yeny Rojas) which has been read in January 2016.
Institution: Servicio Madrileño de Salud
Contact: Hospital Universitario de Getafe · Ctra. Toledo km. 12,5. 28905 Madrid
Tel.: 916834982 · E.mail: [email protected] · Website: http://www.ciberes.org
CIBERES I Annual report 2015 I 79