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• Cellular and molecular basis of depression and of the mechanism of action of the antidepressants . Intracellular signalling targets . Phenotypic and molecular characterisation .
• New therapeutic targets . Neuroplasticity and serotonergic neurotransmission . Endocannabinoid system and antidepressant responses .
• New therapeutic tools in depression: small interfering RNA (siRNA), ketamine, new psychothera- peutic strategies .
• Deep brain stimulation . Clinical trials in patients and animal models . • Validation of various instruments of evaluation and change in patients with depression . • MRI study in different stages of major depression . • Origin and consequences of the neuroinflammation in depression . • Treatment with ECT: relationship with neuropsychological impairments and quality of life .
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