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DEPRESSION PROGRAMME
Víctor Pérez Sola (G21) Coordinator
The mission of the CIBERSAM Depression Programme is to carry out collaborative projects between basic and
clinical researchers: ranging from animal models to patients, genetics to clinical, including neurochemistry and molecular biology . For that purpose, the programme includes clinical and basic groups with extensive experience in translational research . In 2014 and as a result of the work conducted in previous years, several collaborative intramural and extramural projects focusing on basic research, new therapeutic targets and genes-environment interaction, neuroimaging studies and clinical trials that have allowed evaluating pharmacological and physical therapies in refractory depression were concluded in the programme . A line of research focusing on the risk factors of suicide, and on the consolidation and evaluation of specific programmes for the prevention of suicidal behaviour was also consolidated .
The research projects in the programme focus on 3 main focal points: Epidemiology and prevention of depression and suicide; neurobiological basis of mood disorders; efficacy, resistance and new therapeutic targets in depression .
Structure of the Programme
Coordinator: Víctor Pérez Sola – G21 Groups involved in the programme: • G02 Instituto de Investigaciones Biomédicas (Francesc Artigas Pérez) • G03 Hospital Universitario La Princesa (José Luis Ayuso Mateos) • G06 Universidad de Granada . Facultad de Medicina (Jorge A . Cervilla Ballesteros) • G17 Hospital Universitario de Bellvitge (José Manuel Menchón Magriña) • G20 Universidad de Santander . Facultad de Medicina (Ángel Armando Pazos Carro) • G21 Hospital Santa Creu i Sant Pau / Hospital Mar (Víctor Pérez y María J . Portella)
Specific objectives of the Depression Programme
Description of the main lines of research of the programme:
• Analysis of suicidal behaviour; development and evaluation of prevention programmes . Incidence of the suicide, related factors and use of antidepressants in the child and youth population .
• Genes-environment interaction in depression . Genetic predisposition and drug response factors .
• Psychosocial difficulties and occupational disability in patients with depression .
• Sociodemographic, clinical and/or pharmacological factors involved in the response to different therapeutic strategies .
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CIBERSAM » Annual report 2014