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3 . To demonstrate a key role of TLR/NLR receptor activation in the pathogenesis of ALI . These effects will be studied in animal models of ALI and in serum from patients with ALI, as well as in different cell types and in isolated ventilated perfused lung model .
4 . To define the relationship of asynchronies to clinically relevant outcomes in patients with ALI, in order to define therapeutic targets based on ventilatory management and to define ventilatory management strategies
5 . To explore lung repair mechanisms that are initiated immediately following the insult leading to ALI/ARDS (i .e . sepsis, VILI) . To study interactions between initiating factors, structural pulmonary elements, and signalling pathways that are involved in lung repair .
To define biochemical factors determining changes in surfactant function and structure in a rat model of ALI . To define mechanisms of alveolar repair, by means of stem cells, in decellularized lung scaffolds and in a lung-on-a-chip model . To use of adult stem cells in treatment .
6 . To spread knowledge and evidence providing new insights and training on acute lung injury mechanisms and lung repair.
Main results until the end of 2014
• Location of new genes, genetic variants and microRNA for identifying the predisposition, underlying histological lesion and prognosis of the Acute Respiratory Distress Syndrome .
• First-time identification of the incidence in Spain and worldwide of the ARDS . • New diagnostic criteria of ARDS, classifying it in three levels of severity (Berlin Definition, Consensus
Conference) .
• Description of the worldwide practice of the mechanical ventilation patterns in patients in the ICU, and in the different subgroups, according to the different pathologies that are a cause of acute respiratory failure .
• Design of a new continuous monitoring technique of critical patients .
• Design of a lung model from the extracellular matrix .
• Characterisation of the nanomechanics of the extracellular matrix of the lung by means of atomic force microscopy .
OTHER RELEVANT RESULTS OF THE CRP:
• Patent: Compuesto derivado de urea pirimidínica para el tratamiento de enfermedades inflamatorias . Application Number: P201031978 .
• Patent: Uso de un compuesto químico derivado de un pirrol 1, 2, 3, 5-tetrasustituido en la preparación de un medicamento útil para el tratamiento de enfermedades inflamatorias que cursan con procesos apoptóticos celular . Application Number: P201131785 .
• Patent: Marker for assessing the risk of developing acute kidney injury . Application/publication code: EP 12382393 .2
• Patent: Nanopartículas recubiertas de gelatina . Application/publication code: P201231038 • Better Care spin off CSPT: project for the analysis of digital respiratory signals .
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