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role of the primary cilium of cholangiocytes, as well as the development of vari-

ous hepatic chronic diseases (ie, chronic liver damage, NAFLD, hemochromatosis)
and biliary diseases (ie, polycystic liver disease, primary sclerosing cholangitis,

primary biliary cirrhosis).

• M tv, r BN, s aJ, B JM, g sa, h B. Pasireotide is
Most relevant asyuKaDtKetroopeaNaLesraDiLoNeuaNg
more effective than octreotide in reducing hepatorenal cystogenesis in rodents with
scientific
polycystic kidney and liver diseases.Hepatology. 2013 Jul;58(1):409-21.
articles
• roDríguez-soLer M, pérez-CarBoNeLL L, guariNos C, zapater p, CastiLLeJo a, BarBerá vM.
Risk of cancer in cases of suspected lynch syndrome without germline mutation.

Gastroenterology. 2013 May;144(5):926-932.e1; quiz e13-4.

• BuJaNDa L, LaNas á, QuiNtero e, CasteLLs a, sarasQueta C, CuBieLLa J. Effect of aspirin and
antiplatelet drugs on the outcome of the fecal immunochemical test.Mayo Clin Proc.

2013 Jul;88(7):683-9.
ñ

• perugorria MJ, Murphy LB, FuLLarD N, ChaKraBorty JB, vyrLa D, WiLsoN CL et aL.. Tumor
progression locus 2/Cot is required for activation of extracellular regulated kinase
í
in liver injury and toll-like receptor-induced TIMP-1 gene transcription in hepatic

stellate cells in mice.Hepatology. 2013 Mar;57(3):1238-49.

• artaL-MartNez De NarvaJas a, goMez ts, zhaNg Js, MaNN ao, taoDa y, gorMaN Ja et aL..
Epigenetic regulation of autophagy by the methyltransferase G9a.Mol Cell Biol. 2013

Oct;33(20):3983-93.

During the last year our scientific activity and production has significantly in-
Highlights
creased due to the incorporation of two internationally recognized postdoctoral

researchers through the Ikerbasque program (Dr. Bañales and Dr. Perugorria).

Dr. Baales leads the hepatobiliary area in our research group and has significant
national and international collaborations as well as different research projects

related to the hepatobiliary pathophysiology and oncology. Currently there are 5

pre-doctoral researchers who are developing their research projects in our group.
In the gastrointestinal oncology area is important to emphasize the implementa-

tion of the EPICOLON III project, not only because of the online data collection
but also for the development of projects seeking new diagnostic biomarkers in

colorectal cancer. An important step during the past year has been the end of the

study on precursor lesions of gastric cancer that will lead to significant advances
in this field.

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