Page 60 - MemoriaEHD-Eng

RESEARCH GROUPS

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PROGRAMME:
G1081
Liver Cancer and Cancer of
the Digestive System

Group Members
Lead Researcher

Bujanda Fdez. de Pierola, Luis
STAFF MEMBERS
Goitia Viaa, Ana Isabel

Gutierrez Stampa, M. Pilar
Contact:
Muoz Garrido, Patricia
Hospital Donostia

Paseo Dr. Beguiristain, s/n. San Sebastián, Guipúzcoa. ASSOCIATED MEMBERS
Phone: (+34) 659 781 746 Arenas Ruiz-Tapiador, Juan

E.mail: [email protected] Baales Asurmendi, Jess Ma
Website: https://intranet.cientifis.com/CiberEHD/intranet/
Cosme Jimnez, Angel

Herreros Villanueva, Marta
Hijona Muruamendiaraz, Elizabeth
Main lines of research
Perugorria Montiel, Mara Jess

Cancer is the leading cause of death in men and the second in women.

Colorectal cancer (CRC) has the largest incidence worldwide and the second
in mortality. Our goal is to determine the best test for the early diagnosis

of this disease as well as to improve its acceptance in screening programs.

Other projects include the identification of genetic factors that promote its 13
appearance, response to treatment and the adverse effects of the treatment 20
T
(EPICOLON I, II EPICOLON, EPIPOLIP, EPINEO, COLONPREV, SmartHEALTH, R
EPICOLON III studies). Intestinal metaplasia is a precursor lesion of gastric PO
E
cancer. Genetic and environmental factors associated with progression are L R
A
unknown. Identifying these factors will help us to develop more effective NU
prevention programs in these patients. Moreover, we are focused on the N
A
study of new pathogenic mechanisms in order to create new treatments /
and early diagnostic strategies in different gastrointestinal tumors with poor HD
E
prognosis (i.e., pancreatic cancer, cholangiocarcinoma, hepatocellular carci- ER
IB
noma and gastric cancer). In the hepatobiliary pathophysiology, our aim is C
to identify the molecular mechanisms involved in: the generation and regu-
60
lation of bile, the pathophysiology of the microvesicles (ie exosomes), the