Page 34 - MemoriaEHD-Eng

HORIZONTAL PLATFORMS

Strategic Actions and Program

One of the global objectives of CIBEREHD is to share resources and infrastructures
between groups.

The platforms and strategic actions of CIBEREHD are constituted as clusters of tech-

nical-scientific equipment with a specific functionality, intended for offering top-level
technological resources to CIBEREHD research groups and external groups, under the

established conditions.

EFFECTS OF WEIGHT REDUCTION ON PORTAL PRESSURE IN

PATIENTS WITH COMPENSATED CIRRHOSIS OF THE LIVER AND

EXCESS WEIGHT/OBESITY

This strategic action was created for the purpose of studying a homogenous group of

compensated cirrhosis patients who suffer excess weight and obesity of any degree.

A significant weight reduction is expected to be associated with a significant portal
pressure reduction, confirming that it is possible to obtain this result by means of non-

pharmacological intervention.

Primary objective

To assess the effect of the weighted reduction obtained after 4 months of diet and
physical exercise on portal hypertension, estimated by means of measuring GPVH in

cirrhosis patients suffering excess weight or obesity.

Secondary objectives

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• To assess the effect of the weighted reduction obtained after 4 months of diet T
R
and physical exercise on liver function estimated by means of indocyanine green PO
clearance and standard liver function tests in cirrhosis patients suffering excess E
L R
weight and obesity.
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NU
• To assess the effect of the weighted reduction obtained after 4 months of diet and N
A
physical exercise on fibrosis markers, endothelial dysfunction and oxidative stress /
and angiogenesis. This will enable better understanding the physiopathological HD
E
mechanisms through which obesity affects liver disease.
ER
IB
C

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