Page 36 - MemoriaDEM-Eng

RESEARCH GROUPS

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Endocrinology and Metabolism
PROGRAMME:

Group Members
Lead Researcher

STAFF MEMBERS
lvarez Escolá, Carmen

Fernndez Millan, Elisa

Contact:
ASSOCIATED MEMBERS
Escriva Pons, Fernando
Facultad de Farmacia. Univ. Complutense de Madrid.
Ciudad Universitaria, S/N. 28040 Madrid. Lizrraga Mollinedo, Esther

Phone: (+34) 91 394 18 57 Martn Arribas, Mara ngeles
E.mail: [email protected] · Website: http://www.ucm.es/biomol2

Main lines of research

The identification of the cellular and molecular mechanisms that link poor

perinatal growth and increased risk of metabolic syndrome and type 2 dia-

betes in adult life through the use of animal models of nutritional manipula-
tion: maternal undernutrition followed or not by overnutrition. To this end

we have focused on:

• The effect of nutrients on the growth, death and function of pancreatic alfa
and beta cells: involvement of different growth factors.

• The potential role of incretins (GLP-1 and GIP) in the relationship between 13
intrauterine growth restriction and the development of type 2 diabetes in 20
T
adulthood: study of the entero-insular axis.
R
PO
• Changes in insulin/glucagon plasma levels and liver sensitivity associated E
L R
with early undernutrition which could alter the available substrates for the A
growing brain.
NU
N
• Impact of early undernutrition on the insulin and leptin hypothalamic re- A
/
sponses and the hypothalamic expression of orexigenic and anorexigenic EM
D
factors (NPY, POMC).
ER
B
• The effect of early undernutrition followed by an overcaloric diet on the CI
obesity risk and the white adipose tissue metabolism.
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