Page 71 - MemoriaCIBER2019-ENG

CIBEREHD 71
Platforms
Bioinformatics Platform
Coordinator: Juanjo Lozano Salvatella
The Bioinformatics platform is actively collaborating in the operation of this CIBER, with 2019 being a succesful year, as reflected in the 20 publications resulting from its support. The collaboration established with the colon cancer area has generated a very relevant publication related to the development of a genetic signature that increases the power to detect hemoglobin levels:
• Identification and Validation of MicroRNA Profiles in Fecal Samples for Detection of Colorectal Cancer. Du- ran-Sanchon S, Moreno L, Augé JM, Serra-Burriel M, Cuatrecasas M, Moreira L, ... Castells A. Gastroenterolo- gy. 2020 Mar;158(4):947-957.e4. doi: 10.1053/j.gastro.2019.10.005. Epub 2019 Oct 14
As part of a team of researchers from 24 institutions -including CIBEREHD- and organisations from nine European countries, coordinated and led from Barcelona by the European Foundation for the Study of Chronic Liver Failure (EF Clif), the blood metabolic signature - or “molecular signature” - of Acute on Chronic Liver Failure (ACLF) has been identified:
• Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mecha- nism underlying ACLF.Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ,Junot C, ... V, Angeli P; j Hepatol. 2019 Nov 25. pii: S0168-8278(19)30696-8. doi: 10.1016/j.jhep.2019.11.009. [Epub ahead of print]
Collaboration with CIBEREHD groups and other national and international groups continues to generate highly rele- vant publications. In the area of inflammation in liver disease we have the following:
• Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, ... Bataller R.
• Nat Commun. 2019 Jul 16;10(1):3126. doi: 10.1038/s41467-019-11004-3.