Page 116 - MemoriaCIBER2019-ENG

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CIBER Annual report 2019
Programmes
P1: Epidemiology and control of chronic diseases
Coordinator: Ma José Sánchez Pérez
The Programme has continued with the scientific activity of the three strategic subprogrammes.
MCC-Spain
The MCC-Spain project, led by Manolis Kogevinas and Marina Pollán, is being used as a study of prognostic factors in patients with colorectal, breast or prostate cancer to find out what previous exposures, patient or tumor characte- ristics or the treatments received influence overall and disease-free survival. 4,837 cases of these cancers have been followed up. An article has been published describing the monitoring methodology and the characteristics of the 3 prospective cohorts (Alonso-Molero J, Molina AJ, Jiménez-Moleón JJ, et al, 2019).
In 2019, 15 scientific articles were published in indexed journals. One of the most impactful articles aimed to assess the correlation between pro-inflammatory and antioxidant dietary intake with the risk of developing colorectal and breast cancer (Obón-Santacana M, Romaguera D, Gracia-Lavedan E, et al), showing an association between the risk of colorectal cancer and the inflammatory potential of the diet, as well as the combination effect between the inflam- matory potential of the diet and the total antioxidant capacity of the diet plan. However, there was no evidence of increased risk of breast cancer.
Gen-Risk
The Gen-risk project, led by Víctor Moreno, is funded by the Fundación Científica de la Asociación Española contra el Cáncer (Scientific Foundation of the Spanish Association against Cancer-AECC), and is largely supported by the MCC- Spain study. Its objective is to improve cancer prevention through personalised strategies, looking for biomarkers that can be used to identify which people have the highest risk of developing one of the 5 cancers included in the study (colorectal, breast, stomach, prostate and Chronic lymphocytic leukemia), to better guide the prevention of these tumors, reducing both morbidity and the social and economic impact that they entail.
During the first year, 6,375 DNA samples were collected, with which an analysis of the complete genome will be ca- rried out, to combine the data with another 2,463 samples for which this data is already available. The extraction of DNA from 402 blood and 65 saliva samples has been carried out, as well as the aliquoting of 562 DNA samples in the appropriate format to carry out the quantification and normalisation prior to genotyping.