Page 103 - MemoriaCIBER2019-ENG

CIBERES 103
• Sleep Disordered Breathing Is Highly Prevalent in Patients with Lung Cancer: Results ofthe Sleep Apnea in Lung Cancer Study. Autores: Cabezas E, Pérez-Warnisher MT, Troncoso MF, Gómez T, Melchor R, Pinillos EJ, ElHachem A, Gotera C, Rodríguez P, Mahillo Fernández I, Martínez-García MÁ, González-Mangado., Pe- ces-Barba G, Seijo LMJournal: Respiration; international review of thoracic diseases Publication date: 2019- 01-01DOI: 10.1159/000492273.
Sleep Line
• Villanueva et al. accuracy of one-night actigraphy for estimating sleep in patients with sleep apnea. Sleep Med. 2019.
• Cabezas E, Pérez-Warnisher MT, Gómez T, Melchor R, Pinillos EJ, El Hachem A, Gotera C, Rodríguez P, Mahillo Fernández I, Martínez-García MÁ; González-Mangado, Peces-Barba G, Seijo LM. Sleep Disordered Breathing Is Highly Prevalent in Patients with Lung Cancer: Results of the Sleep Apnea in Lung Cancer Study. Respi- ration 2019; 97(2): 119 a 124. doi: 10.1159/000492273.
• Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing. Shin MK, Kim LJ, Caballero-Eraso C, Polotsky VY. J Vis Exp. 2019 Oct 25;(152). doi: 10.3791/60298.
• Campos-Rodriguez F, Asensio-Cruz MI, Cordero-Guevara J, Jurado-Gamez B, Carmona-Bernal C, Gonza- lez-Martinez M, Troncoso MF, Sanchez-Lopez V, Arellano-Orden E, Garcia-Sanchez MI, Martinez-Garcia MA; Spanish Sleep Network. Effect of continuous positive airway pressure on inflammatory, antioxidant, and depression biomarkers in women with obstructive sleep apnea: a randomized controlled trial.Sleep. 2019 Oct 9;42(10). pii: zsz145. doi: 10.1093/sleep/zsz145.
Infectious Respiratory Diseases
Coordinator: Antoni Torres Martí Host-Pathogen Interaction Line
• Advances in the use of a bioinformatics tool that combines clinical-epidemiological data of patients and genetic characteristics of the pathogenic microorganism.
• Mutation S110L of H1N1 influenza virus hemagglutinin is a potent determinant of viral attenuation.
• Using Streptococcus pneumoniae capsular polysaccharide microarrays (CPSs), detection of anti-CPS IgGs in serum is possible using very small amounts of sample.
• Study of Haemophilus spp. reveals involvement of hemin uptake systems in H. influenzae infection, as well as importance of H. parainfluenzae as a multidrug-resistant opportunistic pathogen, supported by the description of the first capsular operon in this pathogen and publication of an optimization of the sensiti- vity to co-trimoxazole protocol.
• Two enzybiotics capable of hydrolyzing different peptidoglycan linkages have synergistic bactericidal ac- tivity against pneumococcus, esters of bicyclic amine are effective on mixed S. pneumoniae-H influenzae biofilms, and the dual antimicrobial-immunomodulatory polyphenols and lipid component of lung surfac- tant have a protective effect against H. influenzae.
Tuberculosis Line
Diagnosis. Algorithm for diagnosis of childhood TB developed, including incipient forms. Respiratory specimen trans- port and stabilization reagents reduce the sensitivity of cultures and GeneXpert. CD27- and CCR4 + cells are indicative of tuberculosis disease.
Prevention and immune response. Clinical phase of the new MTBVAC tuberculosis vaccine published in Lancet Respi- ratory Medicine.