Page 92 - CIBERES-2015-eng

Research Groups
Group 31
Programme: COPD
Lead Researcher: Ruiz Cabello Osuna, Jesús
Group members
STAFF MEMBERS: Santos Oviedo, Arnoldo de Jesús.
ASSOCIATED MEMBERS: Benito Vicente, Marina | Bilbao Luri, Izaskun | Herranz Rabanal, Fernando | Izquierdo García, José Luís | Lechuga Vieco, Ana Victoria | Pellico Sáez, Juan | Rodríguez Ramírez de Arellano, Ignacio | Villa Valverde, Palmira.
Main lines of research
The group is integrated in the Advanced Imaging Unit (AIU) that was established in the Spanish National Centre for Cardiovascular Imaging in early 2012. It is a multidisciplinary group focused in developing new imaging applications and molecular imaging devel- opments that will expand the molecular and cellular knowledge of the different cardiovascular and pulmo- nary diseases. With this aim our research is focused on 1) Cardiovascular and Pulmonary Imaging 2) Na- nomedicine and radiochemistry and 3) Metabolom- ics. The group offers the scientific community state of the art imaging technologies including five modali- ties: MRI, X-ray CT, nuclear imaging (PET), ultrasound (echocardiography) and optical (bi and tri-dimensional luminescence and fluorescence). In the field of Nano- medicine the group encompasses a nanotechnology and organic chemistry laboratory in which we develop new nanoparticles, molecular probes and biofunction-
alization techniques for the diagnosis and treatment of different cardiovascular and pulmonary diseases. Currently our group produces multifunctional nano- particles for all imaging techniques available at our institution, like Iron Oxide, liposomes, Up-converting Nanophosphors and Gold Nanoparticles, all of them functionalized with different cardiovascular and pul- monary biomarkers. Additionally, a new 68Ga (and from beginning of 2014) 89Zr radiochemistry labo- ratory is fully operative to provide specific PET radi- otracers for nuclear imaging. Finally, the group also has a long experience in the application of metabolic analysis to the study of different pathologies, by the use of Magnetic Resonance Spectroscopy and Mass Spectrometry and different statistical tools developed within the group. Our research projects range from technical developments and chemistry advances to in vitro studies and tracking biological processes in vivo.
92 I Annual report 2015 I CIBERES