Page 69 - CIBERES-2015-eng

Most relevant scientific articles
Research Groups
Gómez-Pastrana D., DominGuez J.. Diagnosis of tu- berculosis in children using mycobacteria-specific cy- tokine responses: Are there reasons for hope?. Ameri- can Journal of Respiratory and Critical Care Medicine. 2015;192(4):409-410.
Latorre i., LeiDinGer P., Backes c., DominGuez J., De souza-GaLvao m.L., maLDonaDo J. et aL. A novel whole- blood miRNA signature for a rapid diagnosis of pul- monary tuberculosis. European Respiratory Journal. 2015;45(4):1173-1176.
moLina-moya B., Lacoma a., Prat c., Pimkina e., Diaz J., García-sierra n. et aL. Diagnostic accuracy study of
Highlights
Following the WHO priorities stated in the “Global Plan to Stop TB post 2015 global TB strategy”, over the last few years researchers belonging to group 17 within CIBERES have generated considerable scien- tific knowledge, with an emphasis on joint publica- tions involving groups form different Programs and collaborations with other national and international groups in the context of the pathogenesis, preven- tion, diagnosis and treatment of tuberculosis. The researchers of this group have continued investi- gating new prophylactic and therapeutic vaccines against tuberculosis, and have also developed new experimental animal models that better reproduce infection and disease in humans. Studies have also been carried out that provide new insights into the resistance of M. tuberculosis and multi-drug resist- ant TB. New procedures have been developed and evaluated for the molecular typing of M. tuberculosis for epidemiological purposes. New immunological techniques to diagnose latent tuberculosis infec- tion have also been evaluated. As a result of this work, the researchers have actively participated in the development of clinical guidelines for the use of new diagnostic tests (interferon-gamma release as-
multiplex PCR for detecting tuberculosis drug resistance. Journal of Infection. 2015;71(2):220-230.
carDona P.-J.. The key role of exudative lesions and their encapsulation: Lessons learned from the pathology of human pulmonary tuberculosis. Frontiers in Microbiolo- gy. 2015;6(JUN).
JorDana-LLuch e., Gimenez m., DoLores QuesaDa m., rivaya B., marco c., Jesús DominGuez m. et aL. Evalua- tion of the broad-range PCR/ESI-MS technology in blood specimens for the molecular diagnosis of bloodstream Infections. PLoS ONE. 2015;10(10)
says-IGRAs) for latent tuberculosis infection. Group 17 members have also developed several research projects related to other respiratory pathogens: S. aureus, M. pneumoniae, S. pneumoniae, H. influen- zae and respiratory viruses. One line of research in which the group has been active in recent years is the assessment of the importance of the inflamma- tory response in respiratory tract infections.
The main objective is to identify and describe path- ogen and host factors that modulate clinical out- come. Researchers belonging to group 17 are cur- rently involved in five projects funded by the EU in the FP7 framework, and in several research projects funded by national agencies (FIS, MINECO, others), the industry and the Administration. We have also developed scientific collaboration with other CIBER.
The research activities of the group have recently generated six new patents and created a spin-off with the aim of commercializing a new probiotic that may allow treatment shortening in latent tuber- culosis infections.
Institution: Hospital Germans Trias i Pujol · Contact: Ctra. de Can Ruti. Camí de les escoles s/n.
08916 Badalona · Tel.: 93 497 88 94 · E.mail: [email protected] · Websites: http://www.gencat.cat/ics/germanstrias/web_micro/ y http://unitatdetuberculosiexperimental.wordpress.com
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