Page 26 - CIBERES-2015-eng

Scientific Programmes
Sleep Apnoeas Syndrome
COORDINATOR: DR . JOSEP Ma MONTSERRAT There have been two basic objectives of the pro-
gramme in 2015:
1. Study and impact of the obstructive sleep ap- noea syndrome (OSA) in special and little-stud- ied populations (ischaemic cardiopathy, elderly subjects, obesity hypoventilation and cancer) to personalise the handling and treatment in
4. Obesity, as a currently transcendent problem and its relationship with OSA and hyper-venti- lation. The clinical and basic data enable clear- ing up and personalising the need for treat- ment in these groups of patients.
As regards the technological aspects, the most important contributions involve:
these groups, which represent a public health, social and even economic problem. All of this has been done on a translational basis.
2. Technological studies with the aim of optimis- ing the treatment and follow-up of the patients.
The most transcendent results with greatest im- pact are the following.
1. OSA and cardiovascular pathology. a) Develop- ment of an international patent to predictively detect which patients with OSA and resistant hypertension are going to respond positively to CPAP, reducing their blood pressure. b) Mul- ti-centre study on OSA and acute coronary pa- thology. This is a seminal study with lengthy development as regards patients and duration. c) Basic studies in murine models confirming the role of hypoxia in vascular lesion and re- modelling.
2. OSA and elderly patients. Original works have been carried out on murine and clinical models which prove that in elderly subjects the pres- ence of OSA with a high apnoea index gives rise to the manifestation of anatomical-patho- logical cerebral symptoms and anomalies. This is a highly relevant study due to the grow- ing demographic problem in which a large percentage of the European population will be senescent in the near future.
3. Cancer and OSA. A totally seminal work has been performed relating cancer and OSA. The results of clinical studies and on animal mod- els confirm their interaction, generating a ma- jor impact on the international scientific com- munity.
1. New simplified diagnostic methodologies at the patient’s home.
2. Creation of networks between the different care levels to deal with patients with the aim of tackling treatment of a complex, chronic and frequently-found illness, such as OSA.
3. Development of TIC platforms for follow-up of patients. All these contributions are carried out with the main aim of performing comprehen- sive cost-effective measures and for transfer to the healthcare system.
Finally, specific mechanisms have been analysed in the programme to describe the relationship be- tween OSA and associated pathology by means of: parabiotic models, analysis of exhaled gases, immunological aspects of OSA, perinatal hyper- oxia and postnatal damage, relationship between OSA, ventilation, hypoxia biomarkers, and the re- lationship in animal models of hypoxia and pul- monary hypertension and their improvement with drugs. Other contributions have been the creation of a spinoff, cooperation with companies and sev- eral national protocols and clinical guides.
26 I Annual report 2015 I CIBERES