Page 19 - CIBERES-2015-eng

Lung Cancer
COORDINATOR: DR . EDUARD MONSÓ
The 2013-2015 Strategic Project of the Corpo- rate Research Programme (PCI) on Lung Cancer (LC) involved the creation of three cohorts, two of these with initial LC identified by the health sys- tem and a third cohort for screening individuals with a risk of LC. In 2015 the follow-up was com- pleted three years after the first initial LC cohort, thus creating a repository of 253 paraffin-embed- ded samples of lung cancer in stages I-IIp at the CIBERES Pulmonary Biobank Consortium. These samples have been analysed by a panel of Pathol- ogists, which has selected 233 samples for mo- lecular analysis. Tissue Microarrays (TMAs) were prepared with these samples and nucleic acids were extracted. The analysis of their biological markers is currently being carried out. The inclu- sion of patients in the second cohort of initial LC is active and covers clinical information, tumour- al tissue, non-tumoural tissue and fresh blood, at the 9 centres taking part. The third screening co- hort was started in 2014 and has already includ- ed 200 individuals, operating on the patients with pulmonary nodules compatible with LC.
The first joint publication of the PCI for lung can- cer in which the methodology of the strategic pro- ject is described was published in 2015 (Eduard Monsó, Luis M. Montuenga, Julio Sánchez de Cos, Cristina Villena and by the Lung Cancer Coopera- tive Group CIBERES-RTICC-SEPAR-Pulmonary Bi- obank Consortium. Biological Marker Analysis as Part of The CIBERES-RTIC Cancer-SEPAR Strate- gic Project on Lung Cancer. Arch Bronconeumol. 2015 Sep;51 (9):462-7). This will be followed in 2016 by those that are generated from the analy- sis of molecular markers which are currently be- ing carried out on patients in the first cohort, with the aim of identifying survival markers three years from diagnosis. The analysis of the second initial cancer cohort will be started in the second half of 2016, and those of the screening cohort in 2017, a period in which it is estimated that the number of cases operated on will be enough to obtain clin- ically significant results.
Scientific Programmes
CIBERES I Annual report 2015 I 19