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BIPOLAR DISORDER PROGRAMME
Eduard Vieta Pascual (G25) Coordinator
Programme Description
Created in 2008, the CIBERSAM Bipolar Disorder Programme is essentially formed by national groups having expertise in translational research with a very high tendency of applying the results to clinical practice . The main objective of this programme is to enhance knowledge about bipolar disorder causes and treatment .
Identification of the Coordinator and Affiliated Groups:
Programme Coordinator: Eduard Vieta Pascual (Hospital Clínico y Provincial de Barcelona) • Hospital Universitario La Princesa (José Luis Ayuso Mateos)
• Universidad de Oviedo . Facultad de Medicina (Julio Bobes García) • Hospital Universitario de Álava (Ana González - Pinto Arrillaga) • FIDMAG Hermanas Hospitalarias (Peter J . Mckenna) • Universidad de Valencia . Facultad de Medicina (Rafael Tabares Seisdedos)
The Bipolar Disorder Programme has a high rate of internationalization and scientific productivity . Some of the most important work conducted in 2014 includes the epidemiological collaborative works between CIBERSAM groups and international groups, genetic studies, structural and functional neuroimaging work, the development and validation of specific psychometric instruments, staging models, participation in the development of guidelines for clinical practice to be applied in the health system, and innovative clinical trials . Examples of said works are the study of the genetic association of lithium response predictors, international consensus on bipolar disorder staging, the guideline for the evaluation of the effectiveness of the psychological intervention in the first psychotic episodes, studies in that same population who have neurocognitive deficiencies and the associated disability, the characterisation of functional cerebral changes in different stages of bipolar disorder, the clinical trial on the effectiveness of a psychoeducational programme for family group intervention in reducing hospitalizations, and the neurocognitive and functional rehabilitation trial . Work continued in the collaborative study with NASA which has allowed advancing in the knowledge about the mechanisms involved in the age of onset of bipolar disorder and in the description of neural networks involved in the manic and depressive stages of the disease . The findings of all these studies have been published in prestigious journals, such as The New England Journal of Medicine, Jama Psychiatry, Schizophrenia Bulletin, Neuropsychopharmacology, Psychotherapy and Psychosomatics, Journal of Clinical Psychiatry, Acta Psychiatrica Scandinavica and European Neuropsychopharmacology .
THE MAIN LINES OF RESEARCH DEVELOPED BY THE BIPOLAR DISORDER PROGRAMME TO DATE INCLUDE:
• Databases: Creating a broad collaborative database with epidemiological, clinical and biological information about bipolar disorder .
• Clinical trials: Conducting clinical trials to determine the efficacy and tolerability of new treatments for bipolar disorder .
14 CIBERSAM » Annual report 2014