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• sauChelli et al, (2015) . Physical activity in anorexia nervosa: how relevant is it to therapy response? - submitted International J Beh Nutrition Phys . Activity
• islaM, MA et al . (2015) . Olfaction in ED and Abnormal Eating Behaviour: A Systematic Review - submitted Eur . Eat Dis . review
• FaGundo, AB et al . (2015) . Modulation of Higher-order Olfaction Components on Executive Functions in Humans - submitted PLOS One
Preliminary results have been presented in different congresses and symposiums over the last year:
B .1) Characterization of patients with extreme weight situations, and with related EDs, based on endocrine- metabolic-genetic parameters (opioid system, endocannabinoids, hormones and cardiovascular markers) and integrating models . A number of studies analysing endocrine-metabolic parameters and integrating models have been published, and there are other studies which are being prepared or were submitted to be published:
• Fernández-aranda et al ., (2014) . Moderate-Vigorous Physical Activity across Body Mass Index in Females: Moderating Effect of Endocannabinoids and Temperament . PLOS ONE, 9 (8):e104534
• Pardo et al ., (2014) . Association of Irisin with Fat Mass, Resting Energy Expenditure, and Daily Activity in Conditions of Extreme Body Mass Index . International Journal of Endocrinology: 857270, 9 pages
• Pastor et al ., (2014) . Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs . J . Lipid Res . 2014 . 55: 966–977
• PuiG et al ., (2015) . Hypothalamic damage is associated with inflammatory markers and worse cognitive performance in obese subjects . J Clin Endocrinol Metab .; 100(2):E276-81
• noGueiras et al . (submitted) . Circulating betatrophin levels are increased in anorexia and decreased in morbid obese women . Submitted to Journal of Clinical Endocrinology & Metabolism .
• Garrido et al . (submitted) An increase in visceral fat is associated with a decrease in the taste and olfactory capacity - Submitted International Journal of Obesity
• Pastor et al ., (in preparation) . Olfaction capacity is inversely associated with circulating levels of the endocannabinoid 2-arachidonoylglycerol and body mass index .
• orteGa, FJ et al (in preparation) . Common genetic variations of taste receptor, type 2, member 38 (TAS2R38) are associated with extreme weight disorders - paper in preparation .
• orteGa FJ et al (in preparation) . Extreme weight conditions and olfactomedin 2 (OLFM2) - paper in preparation .
P4-02. Neurocognition and longitudinal analysis under extreme weight conditions: stability of specific endophenotypes and their association with response to treatment
GENERAL OBJECTIVE:
Analyze the stability of neurocognitive functioning under extreme weight conditions (ranging from anorexia nervosa to obesity) during treatment, and analyze the possible factors associated with the therapeutic response .
SPECIFIC OBJECTIVES:
• Analyze possible changes in neurocognitive endophenotypes (executive and attentional functions), neurodevelopmental and sensory endophenotypes (sleep, olfactory-taste), in extreme weight situations (ranging from anorexia nervosa to obesity, including related eating disorders) after usual treatment .
• Examine the interaction between endocrinological and psychological functioning (personality, psycho- 22 CIBEROBN » Annual report 2014