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effects can be observed in just 3 months after making a lifestyle change, and that supplementing patients with a high vascular risk with healthy foods such as extra-virgin olive oil, dried fruits and nuts, fruits and/or vegetables could be considered . Finally, it should be pointed out that these protective effects are observed in all types and subtypes of evaluated participants (over and under the age of 70 years old, diabetics and non-diabetics, hypertensive and non-hypertensive patients,...), so its effects can generally be applied to the entire population . It is striking that even patients who are carriers of “harmful” polymorphisms benefit from the protective effects of the Mediterranean diet when compared with the negative effects of these poly- morphisms on cardiovascular health . Over 75 papers have been published in high-impact journals, including The New England Journal of Medicine, JAMA, Circulation, Annals of Internal Medicine, Archives of Internal Medicine, Diabetes Care and American Journal of Nutrition .
Throughout the study, annual training courses for researchers, nurses and dieticians were given at the be- ginning of December every year in the Schools of Medicine and Pharmacy at the Universidad de Barcelona in order to provide training for the researchers, nurses and dieticians participating in Predimed 1 and currently in Predimed Plus from Las Palmas de Gran Canarias, Palma de Mallorca, Vitoria, Barcelona, Granada, Mala- ga, Seville, Madrid, Hospitalet de Llobregat, Gerona, Castellón and Reus . A total of between 175 and 200 people attended each year . Over 10 PhD dissertations have also been defended based on papers relating to the PREDIMED study .
The PREDIMED study has been a collaboration model between clinical, basic applied and basic researchers all across Spain . Predimed 1 included the collaboration of researchers from level-three hospitals, universities, CSIC and the primary care area . Specifically 18 centres from 8 Spanish regions (Catalonia, Basque Country, Navarre, Aragon, Valencia, Balearic Islands, Andalusia, Madrid and Canary Islands) . Furthermore, groups from Las Palmas de Gran Canarias, Palma de Mallorca, Vitoria, Barcelona, Granada, Malaga, Seville, Madrid, Hospitalet de Llobregat, Gerona, Castellón and Reus participate in Predimed Plus .
The huge international repercussion of the Predimed 1 results assures the viability and sustainability of Pre- dimed Plus, and therefore the viability of the CIBERobn nutrition programme . The Predimed Plus study seeks to demonstrate that a Mediterranean lifestyle, including intervention with a low-calorie Mediterranean diet, a physical activity programme and behavioural therapy, is effective both in the prevention of cardiovascular complications and in reducing body weight and adiposity parameters . Last year over 1,000 participants were included in Predimed Plus from 10 recruitment centres and at the end of the year, after getting fun- ding, another 12 centres were incorporated, so the recruitment rate will pick up considerably .
16 CIBEROBN » Annual report 2014