Page 27 - MemoriaES-Eng

www.ciberes.org

In our CRP project we will approach asthma as a trans-disciplinary research with

expertise from clinical, epidemiological and biologist researchers to generate new
therapeutic options based in a better diagnosis. In our integrative approach we

will approach immunological, genetic and environmental factors leading

to complex asthma phenotypes in order to identify, describe and validate
immunological and molecular networks involved in the genesis and evo-

lution of asthma. To achieve our aims we propose to study retrospectively and
prospectively two well defined cohorts.

In our project we will focus our interests on the following problems:
Aims and

objectives
• Mechanisms underlying genesis and evolution of asthma.

• Characterization of asthma phenotypes

• í
Characterization of asthma severity and identification of the factors that are in-
volved in asthma severity

• New therapies for asthma

• To identify novel biomarkers and pathways that can be translated into targets for
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therapeutic strategies.
í
• To generate and disseminate expertise and knowledge obtained from the consor-

tium to transfer information to scientific community and society.

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Publications:
Main results

in 2013
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• c c, l B, c MJ, M X. Protein identification of two allergens é
AStilloArAruZuoZ
of Boletus edulis causing occupational asthma. Am J Respir Crit Care

2013;187(10):1146-8.

• Quirce S, MuoZ X, urrutiA i, PreZ-cAMo i, SABAdell c, doMíngueZ-ortegA J,
B P, P V. Changes in the asthma control test score with work-related
ArrAncolAZA
asthma. J Investig Allergol Clin Immunol. 2013;23(4):284-5.

• de llAno lP, VennerA M del c, lVAreZ FJ, MedinA JF, BorderiAS l, Pellicer c, gonZáleZ

H, gullon JA, MArtneZ-MorAgon e, SABAdell c, ZAMArro PicAdo c, MuñoZ X. Effects
of omalizumab in non-atopic asthma: results from a spanish multicenter

registry. J Asthma. 2013;50(3):296-301.

• MArtneZ-gonZleZ i, rocA o, MASclAnS Jr, Moreno r, SAlcedo Mt, BAekelAndt V,
13
cruZ MJ, rello J, ArAn JM. Human Mesenchymal Stem Cells Overexpressing the 20
IL-33 Antagonist sST2 Attenuate Endotoxin-Induced Acute Lung injury. Respir T
OR
Cell Mol Biol 2013;49(4):552-62.
P
ñRE
• B di, k M, l Zl, J VJ, F k, g d, M Jl, L
ernSteinASHonuMMuSoHnSonluHArtYAutrinAloA
cArtier A, Boulet lP, SAStre J, Quirce S, gerMolec d, tArlo MJ, MuoZ X, luSter NU
Mi, Y B. CTNNA3 (alpha-catenin) gene variants are associated with N
uceSoY A
diisocyanate asthma, a replication study in a Caucasian worker population. S /
E
Toxicol Sci. 2013;131(1):242-6.
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