Page 57 - MemoriaEHD-Eng

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• r C, g J, a iK, g i, a s, t M. Rebleeding prophylaxis
Most relevant ipoLLeNesCàrauJorauperaugustiNeJeDor
improves outcomes in patients with hepatocellular carcinoma. A multicenter case-
scientific control study.Hepatology. 2013 Dec;58(6):2079-88.

articles
• Berzigotti a, seiJo s, areNa u, aBraLDes Jg, vizzutti F, garCía-pagáN JC. Elastography,
spleen size, and platelet count identify portal hypertension in patients with compen-

sated cirrhosis.Gastroenterology. 2013 Jan;144(1):102-111.e1.

• La Mura v, pasaríN M, MeireLes Cz, MiQueL r, roDríguez-viLarrupLa a, hiDe D. Effects of
simvastatin administration on rodents with lipopolysaccharide-induced liver micro-

vascular dysfunction.Hepatology. 2013 Mar;57(3):1172-81.

• graCia-saNCho J, garCía-CaLDeró h, hiDe D, MarroNe g, guixé-MuNtet s, peraLta C. Si-
mvastatin maintains function and viability of steatotic rat livers procured for

transplantation.J Hepatol. 2013 Jun;58(6):1140-6.

• rosaDo e, roDríguez-viLarrupLa a, graCia-saNCho J, tripathi D, garCía-CaLDeró h, BosCh
J. Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats.

Hepatology. 2013 Oct;58(4):1424-35.

Highlights
The most prominent research of the group includes the study of new mechanisms
modulating the hepatic vascular tone in cirrhosis and the development of new

therapeutic strategies based on those mechanisms.

During this year, in this sense, we have further characterized the use of simvasta-

tin reducing liver vascular dysfunction in cirrhosis, and in liver protection against
LPS and ischemia-reperfusion injury.

We have also shown that other drugs such as rMnSOD, Resveratrol, Terutroban,

and the Leptin receptor can improve portal hypertension and fibrogenesis in cirr-
hosis.

Importantly, we developed new non-invasive methods to identify significant portal

hypertension with compensated cirrhosis, and validated the use of transition elas-

tography and of metabolomic markers as tools for non-invasive evaluation.

Finally we have developed a new device for hepatic cells co-culture in a sinusoidal-
like environment.

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