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• L i, L-á Mr, C Ja, M-Q Mr, B JM, p J ..
Most relevant egazópezLvarezaMpiLLooyauiLesoLaríNDe La eñaet aL
KIR gene mismatching and KIR/C ligands in liver transplantation: consequences for
scientific short-term liver allograft injury.Transplantation. 2013 Apr 27;95(8):1037-44.

articles

Highlights
The most remarkable finding of our work was the discovery that liver transplant

can mediate innate immunity based on the NK cell alloreactivity, in the same way
as it was previously described for hematopoietic stem cell transplantation, when

this model is applied to rejection (graft versus host). Therefore, NK cell alloactiva-
tion could play a role in early acute rejection episodes in liver transplant recipi-

ents, especially when a recipient that carry either KIR2DL3 or KIR2DS4 gene, or

both genes, receives a liver from a donor that poses HLA-C that does not belong to
allotype C1 (when donor is a homozygote for allotype C2). This finding has led to a

new way of working and prediction of the rejection based on the detection of KIR/

HLA combination that could be useful for better monitoring and individual thera-
peutic follow-up of this transplant’s recipients, in order to prevent side effects and

inherent complications of the immunosuppressor therapy. Moreover, this finding
could serve to demonstrate a new subtype of regulatory lymphocytes TCD8+, as

well as to predict the outcome of the transplant and to define the different biologi-

cal markers in the patients with cirrhosis or infected with hepatitis C virus.

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