Page 30 - MemoriaEHD-Eng

SCIENTIFIC PROGRAMS

P6. Gastrointestinal Inflammation and Motility

The program on Gastrointestinal inflammation and motility, maintains intense net-
working between the groups with stable collaborations crystalizing in achievement

of external funding and high standard outputs.

The area of Neurogastroenterology and Motility has further developed collaborati-
ve studies between the different groups in CIBERehd and with other international

teams. The flourishing areas include the characterization of dismotility patterns and

electrophysiological and ultrastructural alterations in patients with gut dysfunctions.
The former aspect may provide relevant results applicable to the diagnosis and

subclassification of these patients, that may facilitate their clinical management . At

translational level Ciberehd promoted and endorsed the position statements of the
European Society on Swallowing Disorders on best clinical practice for adult patients

with oropharyngeal Dysphagia developed during the 2nd ESSD congress, October
27-27, Barcelona. The cross-task between colonic flora and the host has originated

a new concept in Neurogastroenterology: the microbiotame-gut-brain axis. This

new insight has been presented in an international summit (Microbiota for Health)
in France. This area of research has aroused tremendous interest and has promoted

the incorporation of an international multidisciplinary section within the European

Society of Neurogastroenterology and Motility, led by members of CIBERehd. Fur-
thermore, international summits on “Microbiota for Health”, chaired by CIBERehd

members, have been jointly organized with the American Gastroenterological Asso-
ciation in Evian, France (2012) and Madrid (2013.) The area of Neurogastroentero-

logy and Motility has further developed collaborative studies on electrophysiological

and ultrastructural alterations in patients with gut dysfunctions between the diffe-
rent groups in CIBERehd and with other international teams.

In the subprogram of acid-related diseases, the groups have been actively working

integrated in 2 main collaborative areas. One of them focused on the investigation

of both environmental and genetic factors linked to increased susceptibility to bleed 13
in the GI tract in patients taking NSAIDS or antiplatelet agents. The other area 20
T
deals with investigation in the treatment and management of H. pylori infection in R
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humans, where substantial contributions has been made possible thanks to the ex- E
tensive networks of hospitals leaded by investigators of this area of the CIBERehd. L R
A
Both programs have provided a significant contribution in terms publications and of NU
samples and associated high-quality clinical information for completion of ongoing N
A
genetic analysis in acid-related disease. One of the outstanding ongoing projects /
HD
resulting from the intense networking an collaboration between the grupos of pro- E
gram 6, is the development of a multicenter project aiming at elucidating the causes ER
IB
of gastric cancer progression based on the characterization of clinical, histologic, C

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microbiologic, genetic, epigenetic and epidemiologic factors, in a cohort of patients
diagnosed at least 10 years previously of gastric cancer precursor lesions. This stu-