Page 23 - MemoriaEHD-Eng

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PROJECT 2

Project Title:

Multicentre study for the validation of biomarkers of choice that reflect

the individual response of solid organ transplant recipients to immunosup-
pressive treatment.

Lead Group: Navasa

Principal Investigator: M. Brunet

Collaborating Groups:

CIBEREHD Groups: Álvarez, Parrilla.

Objectives:

The general objective of this study consists of choosing and validating optimal

pharmacodynamic biomarkers, together with pharmacokinetic parameters, which
reflect the individual response to immunosuppressive treatment and are predictive

of the clinical progression of solid organ transplant recipients (acute rejection, in-
fection, toxicity).

Comment: Project in final phase, following the planed phases.
é

PROJECT 3

Project Title:

Control teraputico de la diabetes en pacientes con trasplante hepático

Lead Group: Berenguer
ó
Principal Investigator: M. Berenguer

Collaborating Groups:
CIBEREHD Groups: De la Mata, Parrilla.

Nat. Groups not related to CIBEREHD: T. Serrano (Zaragoza), JI Herrero (Pamplona)

Objective:

To evaluate the degree of therapeutic control of diabetes mellitus in liver transplant

recipients and identifying the factors associated with it.

PROJECT 4

Project Title:

Biomarcadores en el diagnstico diferencial del rechazo celular agudo y la á

recurrencia de la hepatitis C tras el trasplante heptico.

Lead Group: M. Navasa
13
Principal Investigator: M. Navasa 20
T
Collaborating Groups: X. Forns OR
P
CIBEREHD Groups: De la Mata, RE
L
National Groups not related to CIBEREHD. A
NU
Objectives:
N
• A
To evaluate a panel of serological biomarkers in differentiation between acute D /
rejection and hepatitis recurrence after liver transplant.
H
E
• To study if any of the evaluated biomarkers allows predicting response to ER
IB
treatment for cellular rejection.
C

• To determine if these biomarkers allow early identification of patients with 23

serious hepatitis C recurrence the liver transplant.