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SCIENTIFIC PROGRAMS

P3. Cholestasis, Metabolic Disorders and Hepatotoxicity

Program Coordinator

Dr. Juan F. Medina, CIMA Universidad de Navarra

Program 3 includes ten groups, the research activities of which are mainly related to é
Foreword
cholestasis, metabolic disorders and hepatotoxicity. A first branch in the Program is

formed by three groups led by Dr. Albert Parés, Dr. Llorenç Caballería, and Dr. Juan F. í
Medina, respectively. These groups focus on clinical, epidemiological, and basic studies

of cholestasis, and they are working towards the analysis of transport abnormalities of
bile flow components and subsequent alterations in primary biliary cirrhosis and other

chronic cholestatic diseases.
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The other seven groups form a second branch in the program which researches me- ú

tabolic disorders, and, more specifically, the study of steatohepatitis and liver toxicity.
Thus, these groups conduct studies related to the mechanisms of oxidative stress and

apoptosis in hepatocytes and the role of cytokines and adipocytokines in metabolic,

toxicological and infectious liver disorders. Highly relevant in this regard are the acti-
vities carried out by Dr. Jos M. Mato and Dr. José C. Fernández-Checa’s groups, which

have been awarded a substantial number of projects and carry out multiple collabora-
tions with other groups. Moreover, the groups led by Dr. Javier González Gallego, and
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Drs. Carmelo Garca Monzn and Paloma Martn Sanz maintain a close collaboration for

the study of antioxidant therapies in models of hepatitis C. Finally, the groups led by
Dr. Jose V. Castell and Dr. Ral Andrade are investigating different molecular mecha-

nisms that cause hepatotoxicity.

Program Cholestasis, Metabolic Disorders and Hepatotoxicity

Projects and The groups that form Program 3 have maintained collaborative networks among them 13
(intra-Nodal collaborations) and among other external groups (inter- Nodal collabora- 20
Collaborations
T
tions). Dr. Jos M. Mato’s group, from CIC BioGUNE, has significantly potentiated these R
collaborations through their Genomics, Proteomics, Metabolomics and Gene Silencing PO
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Platforms, which are also available to all CIBERehd groups. Also, collaborations based L R
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on these platforms have consolidated through the organisation of formations activities NU
such as training sessions.
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