Page 43 - MemoriaDEM-Eng

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• l G, e-G jC, l e, j j, P C, C a, C M, R e, s-q
Most relevant laVeRIassColàIleRMaulVeonsabRéoFánosánChezuesada
jl, blanCo-VaCa F. Phytosterols inhibit the tumor growth and lipoprotein oxidizability induced
scientific
by a high-fat diet in mice with inherited breast cancer.J Nutr Biochem. 2013;24(1):39-48.
articles
• Mendoza-baRbeRá e, julVe j, nIlsson sk, lookene a, MaRtín-CaMPos jM, RoIG R, leChuGa-sanCho
aM, sloan jh, Fuentes-PRIoR P, blanCo-VaCa F.. Structural and functional analysis of APOA5

mutations identified in patients with severe hypertriglyceridemia.Journal of Lipid Research.
2013;54(3):649-61.

• e-G jC, C X, j j, q h, s d, M j, t M, j M, b-V
sColàIlhenulVeuesadaantosetsoousauhIaInenlanCoaCa
F.. Hepatic lipase- and endothelial lipase-deficiency in mice promotes macrophage-to-fe-
ces RCT and HDL antioxidant propertiesBiochimica Biophysica Acta (Mol Cell Biol Lipids).

2013;183(4):691-7.

• lee-RueCkeRt M, blanCo-VaCa F, koVanen Pt, esCola-GIl jC.. The role of the gut in reverse cho-
lesterol transport--focus on the enterocyte.Progress in Lipid Research. 2013;52(3):317-28.

é
• julVe j, esColà-GIl jC, RodRíGuez-MIllán e, MaRtín-CaMPos jM, jauhIaInen M, quesada h, RenteRía-
obReGón IM, osada j, sánChez-quesada jl, blanCo-VaCa F. Methionine-induced hyperhomocys-
ò
teinemia impairs the antioxidant ability of high-density lipoproteins without reducing in vivo
macrophage-specific reverse cholesterol transport. Mol Nutr Food Res. 2013;57(10):1814-24.

PUBLISHED RESEARCH RESULTS
Highlights
We have demonstrated that: 1) Dietary phytosterols show a protective effect on

breast cancer development; 2) rare apoA-V mutations can be responsible of some

cases of familial hyperchylomicronemia; 3) hepatic lipase- and endothelial lipase-de- à
ficiency affect two well-known HDL antiatherogenic functions, thus constituting po-

tential therapeutic targets; 4) the gut has an emerging role in reverse cholesterol

transport; 5) hyperhomocysteinemia induced by a methionine rich-diet impair several
HDL functions, a concept that links two different cardiovascular risk factors with pro-

tein intake.

BEGINNING OR FUNDING OF NOVEL PROJECTS DURING 2013

• Therapeutic and nutritional strategies based on improvement of antioxidant and an-
ti-inflammatory HDL function in type 2 diabetes and breast cancer. FIS PI12/00291

(2013-15), PI: J.C. Escol Gil. 198.440 euros.

• Efficacy and security in the management of hyperglycemia at hospital discharge.
é
Spanish Diabetes Society-DIA, 2013-2014, PI: A. Pérez, 207.000 euros

• Sara Borrell Contract, ISCIII. Helena Quesada, 75.600 euros, 2013-15.
• Molecular studies on monogenic dislypidemias and construction of diagnostic and

prognostic criteria in patients with familial hypercholesterolemia without identified

mutation. PI: J. Julve, PI, Miguel Servet Program, 2014-18, 323.997 euros.

INTERNALIZATION AND TRAINING
13
20
Three of the main five selected publications of our group in 2013 include researchers T
from other countries (Sweden, Estonia, Finland, and USA).
OR
P
The internalization activities have continued in COST-HDL BM0904 meetings, including RE
L
assistance to summer schools and short visits to other laboratories of young resear- A
NU
chers.
N
Two PhD thesis have been defended (directors, A. Prez, and F. Blanco-Vaca), Univer- A
M /
sitat Autnoma de Barcelona.
E
D
CLINICAL PRACTICE GUIDELINES
ER
B
A. Prez is a coauthor in eight papers in seven national journals on the adoption of CI

the new European guidelines on cardiovascular prevention to the clinical practice in 43
our country.