Page 40 - MemoriaDEM-Eng

RESEARCH GROUPS

ó

á
á
í
é

óá
ó

Ó

PROGRAMME: P2
Diabetes and Cardiovascular

Group Members
Lead Researcher

STAFF MEMBERS
Benito de las Heras, Manuel R.

Fernndez Lpez, Silvia
Garca Gmez, Gema
Contact:
Nieto Vzquez, Iria
Facultad de Farmacia. Univ. Complutense de Madrid.
Ciudad Universitaria, S/N. 28040 Madrid. ASSOCIATED MEMBERS

Phone: (+34) 91 394 17 77 Escribano Illanes, scar
E.mail: [email protected] · Website: www.ciberdem.org
Gmez Hernndez, Almudena

Guilln Viejo, Carlos
Pedromo Loaiza, Liliana
Main lines of research

• Compensatory mechanisms to hepatic insulin resistance: Progression to

type 2 diabetes:

- The role of the liver-pancreas endocrine axis in triggering beta-cell hyper-

plasia.

- The role of autophagy, mitophagy and ER stress in the regulation of beta-

cell pancreatic mass and beta-cell failure.

• Adipose organ inflammatory disease and the cardiovascular damage:

- .- BATIRKO/apoE -/- DKO mice: The role of the compensatory mecha- 13
nisms of insulin resistance in the aggravation/attenuation of inflammation, 20
T
oxidative stress and vascular lesion in the aorta.
R
PO
• Brown fat function/dysfunction and adipose organ inflammatory disease. E
L R
- New mouse models to study energy imbalance and body weight regula-
A
NU
tion: Brown adipose tissue-specific knockout of IGF-1R and IGF-1R/IR DKO.
N
A
- New mouse models of browning: Brown adipose tissue-specific knockout /
EM
of p85 alpha/PI 3 kinase.
D
ER
• Molecular mechanisms of insulin resistance:
B
CI
- The role of IR isoforms in cardiomyocytes, endothelial and aortic vascular
40
smooth muscle cells.