Page 54 - MemoriaBBN-Eng

TECHNOLOGICAL OFFER

Technological Offer

Following the process for protecting inventions, abstracts were prepared with non-

confidential information of these patent applications, updating the technological offer
of the CIBER-BBN:

• DELIVERY OF SUBSTANCES TO SENESCENT CELLS

Spanish Patent Application P201231370

International Patent Application PCT/ ES2013/070581

This invention refers to nanodevices for controlled and specific delivery of substances

(drugs, bio-actives, markers, cosmetics) to senescent cells. The nanodevice compris-

es a carrier enclosing the cargo and allowing its liberation when targeted cells are
reached, by means of the interaction with senescence-associated beta-galactosidase

(SA-β-Gal). Therefore, it is useful for senescence studies, prevention and treatment

of senescent-associated diseases. Besides others where β-Gal is specifically present
or increased. The invention also comprises preparation procedures and uses of the

nanodevice. The invention belongs to the pharmaceutical and cosmetic fields.

• FUNCTIONALIZED LIPOSOMES USEFUL FOR THE DELIVERY OF BIOACTIVE
COMPOUNDS

International Patent Application PCT/EP2013/063646

The present invention is related to a new kind of functionalized liposome, for the selec-

tive delivery of active agents. This liposome carries a conjugate, by means of function-

alizing the sterol present in its lipid bi-layer with a polymer, linked by a no-carbamate
bond (differing from the state of the art). Besides, the polymer is also functionalized

with a guiding ligand. This conjugate improves the physical-chemical properties of its

carrying vesicles, making these more stable and homogeneous. A procedure for their 13
preparation, a pharmaceutical composition containing these liposomes, and their thera- 20
T
peutic use are described as well.
R
PO
E
L R
• AMPHIPHILIC COPOLYMERS WITH ANTITUMORAL PROPERTIES
A
NU
Spanish Patent Application P201230679
N
A
International Patent Application PCT/ES2013070287
/
BN
The present invention describes the use of a family of amphiphilic co-polymers that B
R-
form micro- or nano-micelles, with intrinsic anti-tumoral activity, and also serving as BE
vehicles for other anti-tumoral agents.
CI

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